Yuan, Ying (Professor of biostatistics)
Bayesian designs for phase I-II clinical trials / Ying Yuan, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Hoang Q. Nguyen,The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Peter F. Thall The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. - xiv, 310 pages : illustrations ; 24 cm - Chapman & Hall/CRC Biostatistics series .
Includes bibliographical references (pages 283-300) and index.
Why conduct phase I-II trials? -- The phase I-II paradigm -- Establishing priors -- Efficacy-toxicity trade-off-based designs -- Designs with late-onset outcomes -- Utility-based designs -- Personalized dose finding -- Combination trials -- Optimizing molecularly targeted agents -- Optimizing doses in two cycles -- Optimizing dose and schedule -- Dealing with dropouts -- Optimizing intra-arterial tPA -- Optimizing sedative dose in preterm infants.
9780367828912
2016004874
101704311 DNLM
Clinical trials--Statistical methods.
Drugs--Testing--Statistical methods.
Bayesian statistical decision theory.
Clinical Trials, Phase I as Topic.
Clinical Trials, Phase II as Topic.
Statistics as Topic.
Bayes Theorem.
Dose-Response Relationship, Drug.
Bayesian statistical decision theory.
Clinical trials--Statistical methods.
Drugs--Testing--Statistical methods.
615.50724 / YUA-B
2017 C-661 QV 771.4
Bayesian designs for phase I-II clinical trials / Ying Yuan, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Hoang Q. Nguyen,The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Peter F. Thall The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. - xiv, 310 pages : illustrations ; 24 cm - Chapman & Hall/CRC Biostatistics series .
Includes bibliographical references (pages 283-300) and index.
Why conduct phase I-II trials? -- The phase I-II paradigm -- Establishing priors -- Efficacy-toxicity trade-off-based designs -- Designs with late-onset outcomes -- Utility-based designs -- Personalized dose finding -- Combination trials -- Optimizing molecularly targeted agents -- Optimizing doses in two cycles -- Optimizing dose and schedule -- Dealing with dropouts -- Optimizing intra-arterial tPA -- Optimizing sedative dose in preterm infants.
9780367828912
2016004874
101704311 DNLM
Clinical trials--Statistical methods.
Drugs--Testing--Statistical methods.
Bayesian statistical decision theory.
Clinical Trials, Phase I as Topic.
Clinical Trials, Phase II as Topic.
Statistics as Topic.
Bayes Theorem.
Dose-Response Relationship, Drug.
Bayesian statistical decision theory.
Clinical trials--Statistical methods.
Drugs--Testing--Statistical methods.
615.50724 / YUA-B
2017 C-661 QV 771.4