Bayesian designs for phase I-II clinical trials / Ying Yuan, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Hoang Q. Nguyen,The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Peter F. Thall The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
Material type:
TextSeries: Publisher: Boca Raton : CRC Press,Taylor & Francis Group, 2016Description: xiv, 310 pages : illustrations ; 24 cmContent type: - text
- unmediated
- volume
- 9780367828912
- Clinical trials -- Statistical methods
- Drugs -- Testing -- Statistical methods
- Bayesian statistical decision theory
- Clinical Trials, Phase I as Topic
- Clinical Trials, Phase II as Topic
- Statistics as Topic
- Bayes Theorem
- Dose-Response Relationship, Drug
- Bayesian statistical decision theory
- Clinical trials -- Statistical methods
- Drugs -- Testing -- Statistical methods
- 615.50724 YUA-B
- 2017 C-661
- QV 771.4
| Item type | Current library | Collection | Call number | Status | Date due | Barcode | Item holds | |
|---|---|---|---|---|---|---|---|---|
Reference
|
RGU Central Library Reference | Reference | 615.50724 YUA-B (Browse shelf(Opens below)) | Not for loan | 77875 |
Includes bibliographical references (pages 283-300) and index.
Why conduct phase I-II trials? -- The phase I-II paradigm -- Establishing priors -- Efficacy-toxicity trade-off-based designs -- Designs with late-onset outcomes -- Utility-based designs -- Personalized dose finding -- Combination trials -- Optimizing molecularly targeted agents -- Optimizing doses in two cycles -- Optimizing dose and schedule -- Dealing with dropouts -- Optimizing intra-arterial tPA -- Optimizing sedative dose in preterm infants.
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